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Fluoroquinolone resistance does not impose a cost on the fitness of Clostridium difficile in vitro.


ABSTRACT: Point mutations conferring resistance to fluoroquinolones were introduced in the gyr genes of the reference strain Clostridium difficile 630. Only mutants with the substitution Thr-82?Ile in GyrA, which characterizes the hypervirulent epidemic clone III/027/NAP1, were resistant to all fluoroquinolones tested. The absence of a fitness cost in vitro for the most frequent mutations detected in resistant clinical isolates suggests that resistance will be maintained even in the absence of antibiotic pressure.

SUBMITTER: Wasels F 

PROVIDER: S-EPMC4325769 | biostudies-literature |

REPOSITORIES: biostudies-literature

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