Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC4333066 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Li Yinqing Y Jiang Yun Y Chen He H Liao Weixi W Li Zhihua Z Weiss Ron R Xie Zhen Z
Nature chemical biology 20150202 3
An important goal of synthetic biology is the rational design and predictable implementation of synthetic gene circuits using standardized and interchangeable parts. However, engineering of complex circuits in mammalian cells is currently limited by the availability of well-characterized and orthogonal transcriptional repressors. Here, we introduce a library of 26 reversible transcription activator-like effector repressors (TALERs) that bind newly designed hybrid promoters and exert transcriptio ...[more]