Ontology highlight
ABSTRACT:
SUBMITTER: Scheffer LL
PROVIDER: S-EPMC4333728 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Scheffer Luana L LL Sreetama Sen Chandra SC Sharma Nimisha N Medikayala Sushma S Brown Kristy J KJ Defour Aurelia A Jaiswal Jyoti K JK
Nature communications 20141223
In muscle and other mechanically active tissue, cell membranes are constantly injured, and their repair depends on the injury-induced increase in cytosolic calcium. Here, we show that injury-triggered Ca(2+) increase results in assembly of ESCRT III and accessory proteins at the site of repair. This process is initiated by the calcium-binding protein-apoptosis-linked gene (ALG)-2. ALG-2 facilitates accumulation of ALG-2-interacting protein X (ALIX), ESCRT III and Vps4 complex at the injured cell ...[more]