Ontology highlight
ABSTRACT:
SUBMITTER: Sonder SL
PROVIDER: S-EPMC6491720 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Sønder Stine Lauritzen SL Boye Theresa Louise TL Tölle Regine R Dengjel Jörn J Maeda Kenji K Jäättelä Marja M Simonsen Adam Cohen AC Jaiswal Jyoti K JK Nylandsted Jesper J
Scientific reports 20190430 1
The plasma membrane of eukaryotic cells forms the essential barrier to the extracellular environment, and thus plasma membrane disruptions pose a fatal threat to cells. Here, using invasive breast cancer cells we show that the Ca<sup>2+</sup> - and phospholipid-binding protein annexin A7 is part of the plasma membrane repair response by enabling assembly of the endosomal sorting complex required for transport (ESCRT) III. Following injury to the plasma membrane and Ca<sup>2+</sup> flux into the ...[more]