Ontology highlight
ABSTRACT:
SUBMITTER: Skowyra ML
PROVIDER: S-EPMC6195421 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Skowyra Michael L ML Schlesinger Paul H PH Naismith Teresa V TV Hanson Phyllis I PI
Science (New York, N.Y.) 20180401 6384
Endolysosomes can be damaged by diverse materials. Terminally damaged compartments are degraded by lysophagy, but pathways that repair salvageable organelles are poorly understood. Here we found that the endosomal sorting complex required for transport (ESCRT) machinery, known to mediate budding and fission on endolysosomes, also plays an essential role in their repair. ESCRTs were rapidly recruited to acutely injured endolysosomes through a pathway requiring calcium and ESCRT-activating factors ...[more]