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In silico analysis suggests interaction between Ebola virus and the extracellular matrix.


ABSTRACT: The worst Ebola virus (EV) outbreak in history has hit Liberia, Sierra Leone and Guinea hardest and the trend lines in this crisis are grave, and now represents a global public health threat concern. Limited therapeutic and/or prophylactic options are available for people suffering from Ebola virus disease (EVD) and further complicate the situation. Previous studies suggested that the EV glycoprotein (GP) is the main determinant causing structural damage of endothelial cells that triggers the hemorrhagic diathesis, but molecular mechanisms underlying this phenomenon remains elusive. Using the informational spectrum method (ISM), a virtual spectroscopy method for analysis of the protein-protein interactions, the interaction of GP with endothelial extracellular matrix (ECM) was investigated. Presented results of this in silico study suggest that Elastin Microfibril Interface Located Proteins (EMILINs) are involved in interaction between GP and ECM. This finding could contribute to a better understanding of EV/endothelium interaction and its role in pathogenesis, prevention and therapy of EVD.

SUBMITTER: Veljkovic V 

PROVIDER: S-EPMC4333865 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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In silico analysis suggests interaction between Ebola virus and the extracellular matrix.

Veljkovic Veljko V   Glisic Sanja S   Muller Claude P CP   Scotch Matthew M   Branch Donald R DR   Perovic Vladimir R VR   Sencanski Milan M   Veljkovic Nevena N   Colombatti Alfonso A  

Frontiers in microbiology 20150219


The worst Ebola virus (EV) outbreak in history has hit Liberia, Sierra Leone and Guinea hardest and the trend lines in this crisis are grave, and now represents a global public health threat concern. Limited therapeutic and/or prophylactic options are available for people suffering from Ebola virus disease (EVD) and further complicate the situation. Previous studies suggested that the EV glycoprotein (GP) is the main determinant causing structural damage of endothelial cells that triggers the he  ...[more]

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