Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cd4-positive Helper T Cell, Helper T-lymphocyte
DISEASE(S): Type 1 Diabetes Mellitus
SUBMITTER: Marlen Lepper
LAB HEAD: Stefanie M. Hauck
PROVIDER: PXD006223 | Pride | 2017-11-30
REPOSITORIES: Pride
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LEM7320_10_T1D_F1.raw | Raw | |||
LEM7320_11_Control_F1.raw | Raw | |||
LEM7320_12_T1D_F1.raw | Raw | |||
LEM7320_13_T1D_F1.raw | Raw | |||
LEM7320_14_T1D_F1.raw | Raw |
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Journal of proteome research 20171213 1
The pathophysiology underlying the autoimmune disease type 1 diabetes (T1D) is poorly understood. Obtaining an accurate proteomic profile of the T helper cell population is essential for understanding the pathogenesis of T1D. Here, we performed in-depth proteomic profiling of peripheral CD4+ T cells in a pediatric cohort to identify cellular signatures associated with the onset of T1D. Using only 250 000 CD4+ T cells per patient, isolated from biobanked PBMC samples, we identified nearly 6000 pr ...[more]