Ontology highlight
ABSTRACT:
SUBMITTER: Guenova E
PROVIDER: S-EPMC4343151 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Guenova Emmanuella E Skabytska Yuliya Y Hoetzenecker Wolfram W Weindl Günther G Sauer Karin K Tham Manuela M Kim Kyu-Won KW Park Ji-Hyeon JH Seo Ji Hae JH Ignatova Desislava D Cozzio Antonio A Levesque Mitchell P MP Volz Thomas T Köberle Martin M Kaesler Susanne S Thomas Peter P Mailhammer Reinhard R Ghoreschi Kamran K Schäkel Knut K Amarov Boyko B Eichner Martin M Schaller Martin M Clark Rachael A RA Röcken Martin M Biedermann Tilo T
Proceedings of the National Academy of Sciences of the United States of America 20150202 7
Interleukin 4 (IL-4) can suppress delayed-type hypersensitivity reactions (DTHRs), including organ-specific autoimmune diseases in mice and humans. Despite the broadly documented antiinflammatory effect of IL-4, the underlying mode of action remains incompletely understood, as IL-4 also promotes IL-12 production by dendritic cells (DCs) and IFN-γ-producing T(H)1 cells in vivo. Studying the impact of IL-4 on the polarization of human and mouse DCs, we found that IL-4 exerts opposing effects on th ...[more]