Ontology highlight
ABSTRACT:
SUBMITTER: Nishina T
PROVIDER: S-EPMC4345304 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Nishina Tomoko T Numata Junna J Nishina Kazutaka K Yoshida-Tanaka Kie K Nitta Keiko K Piao Wenying W Iwata Rintaro R Ito Shingo S Kuwahara Hiroya H Wada Takeshi T Mizusawa Hidehiro H Yokota Takanori T
Molecular therapy. Nucleic acids 20150113
We developed an efficient system for delivering short interfering RNA (siRNA) to the liver by using α-tocopherol conjugation. The α-tocopherol-conjugated siRNA was effective and safe for RNA interference-mediated gene silencing in vivo. In contrast, when the 13-mer LNA (locked nucleic acid)-DNA gapmer antisense oligonucleotide (ASO) was directly conjugated with α-tocopherol it showed markedly reduced silencing activity in mouse liver. Here, therefore, we tried to extend the 5'-end of the ASO seq ...[more]