Proteomics

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Liver proteome upon in vivo N-acetylgalactosamine-conjugated antisense oligonucleotide silencing of ceramide synthase 2

ABSTRACT: Mouse liver proteome was investigated upon in vivo mouse treatment with a N-acetylgalactosamine-conjugated antisense oligonucleotide engineered to silence ceramide synthase 2 specifically in hepatocytes in vivo. The data is a part of a study on the involvement of ceramide enzymatic machinery in cardiovasular disorders and its potential as a target for the disease treatment.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Liver

SUBMITTER: Sergey Kovalchuk  

LAB HEAD: Sergey Igorevich Kovalchuk

PROVIDER: PXD025957 | Pride | 2023-05-10

REPOSITORIES: Pride

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LUM2_02085_KS_LiverChrister_60ug-10fr_TMTMS2_2hG_FC-150-45In2_fr1.raw Raw
LUM2_02086_KS_LiverChrister_60ug-10fr_TMTMS2_2hG_FC-150-45In2_fr2.raw Raw
LUM2_02087_KS_LiverChrister_60ug-10fr_TMTMS2_2hG_FC-150-45In2_fr3.raw Raw
LUM2_02088_KS_LiverChrister_60ug-10fr_TMTMS2_2hG_FC-150-45In2_fr4.raw Raw
LUM2_02089_KS_LiverChrister_60ug-10fr_TMTMS2_2hG_FC-150-45In2_fr5.raw Raw
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Publications

Silencing of ceramide synthase 2 in hepatocytes modulates plasma ceramide biomarkers predictive of cardiovascular death.

Schmidt Steffen S   Gallego Sandra F SF   Zelnik Iris Daphne ID   Kovalchuk Sergey S   Albæk Nanna N   Sprenger Richard R RR   Øverup Charlotte C   Pewzner-Jung Yael Y   Futerman Anthony H AH   Lindholm Marie W MW   Jensen Ole N ON   Ejsing Christer S CS  

Molecular therapy : the journal of the American Society of Gene Therapy 20210814 4

Emerging clinical data show that three ceramide molecules, Cer d18:1/16:0, Cer d18:1/24:1, and Cer d18:1/24:0, are biomarkers of a fatal outcome in patients with cardiovascular disease. This finding raises basic questions about their metabolic origin, their contribution to disease pathogenesis, and the utility of targeting the underlying enzymatic machinery for treatment of cardiometabolic disorders. Here, we outline the development of a potent N-acetylgalactosamine-conjugated antisense oligonuc  ...[more]

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