Ontology highlight
ABSTRACT:
SUBMITTER: Fischbach H
PROVIDER: S-EPMC4347055 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Fischbach Hanna H Döring Marius M Nikles Daphne D Lehnert Elisa E Baldauf Christoph C Kalinke Ulrich U Tampé Robert R
Nature communications 20150206
Presentation of peptides on major histocompatibility complex class I (MHC I) is essential for the establishment and maintenance of self-tolerance, priming of antigen-specific CD8(+) T cells and the exertion of several T-cell effector functions. Cytosolic proteasomes continuously degrade proteins into peptides, which are actively transported across the endoplasmic reticulum (ER) membrane by the transporter associated with antigen processing (TAP). In the ER lumen antigenic peptides are loaded ont ...[more]