Ontology highlight
ABSTRACT:
SUBMITTER: Leonard JD
PROVIDER: S-EPMC4355161 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Leonard John D JD Narlikar Geeta J GJ
Molecular cell 20150212 5
The ATP-dependent chromatin assembly factor (ACF) spaces nucleosomes to promote formation of silent chromatin. Two copies of its ATPase subunit SNF2h bind opposite sides of a nucleosome, but how these protomers avoid competition is unknown. SNF2h senses the length of DNA flanking a nucleosome via its HAND-SANT-SLIDE (HSS) domain, yet it is unclear how this interaction enhances remodeling. Using covalently connected SNF2h dimers we show that dimerization accelerates remodeling and that the HSS co ...[more]