Ontology highlight
ABSTRACT:
SUBMITTER: Bhardwaj SK
PROVIDER: S-EPMC7680125 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Nature communications 20201120 1
Over the last 3 decades ATP-dependent chromatin remodelers have been thought to recognize chromatin at the level of single nucleosomes rather than higher-order organization of more than one nucleosome. We show the yeast ISW1a remodeler has such higher-order structural specificity, as manifested by large allosteric changes that activate the nucleosome remodeling and spacing activities of ISW1a when bound to dinucleosomes. Although the ATPase domain of Isw1 docks at the SHL2 position when ISW1a is ...[more]