Ontology highlight
ABSTRACT:
SUBMITTER: Boginya A
PROVIDER: S-EPMC6586844 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Boginya Alexandra A Detroja Rajesh R Matityahu Avi A Frenkel-Morgenstern Milana M Onn Itay I
Scientific reports 20190620 1
Chd1 is a chromatin remodeler that is involved in nucleosome positioning and transcription. Deletion of CHD1 is a frequent event in prostate cancer. The Structural Maintenance of Chromosome (SMC) complex cohesin mediates long-range chromatin interactions and is involved in maintaining genome stability. We provide new evidence that Chd1 is a regulator of cohesin. In the yeast S. cerevisiae, Chd1 is not essential for viability. We show that deletion of the gene leads to a defect in sister chromati ...[more]