Ontology highlight
ABSTRACT:
SUBMITTER: Rossier J
PROVIDER: S-EPMC4356748 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Rossier J J Bernard A A Cabungcal J-H JH Perrenoud Q Q Savoye A A Gallopin T T Hawrylycz M M Cuénod M M Do K K Urban A A Lein Ed S ES
Molecular psychiatry 20141216 2
The in situ hybridization Allen Mouse Brain Atlas was mined for proteases expressed in the somatosensory cerebral cortex. Among the 480 genes coding for protease/peptidases, only four were found enriched in cortical interneurons: Reln coding for reelin; Adamts8 and Adamts15 belonging to the class of metzincin proteases involved in reshaping the perineuronal net (PNN) and Mme encoding for Neprilysin, the enzyme degrading amyloid β-peptides. The pattern of expression of metalloproteases (MPs) was ...[more]