Ontology highlight
ABSTRACT:
SUBMITTER: Atherton J
PROVIDER: S-EPMC4358365 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Atherton Joseph J Farabella Irene I Yu I-Mei IM Rosenfeld Steven S SS Houdusse Anne A Topf Maya M Moores Carolyn A CA
eLife 20140910
Kinesins are a superfamily of microtubule-based ATP-powered motors, important for multiple, essential cellular functions. How microtubule binding stimulates their ATPase and controls force generation is not understood. To address this fundamental question, we visualized microtubule-bound kinesin-1 and kinesin-3 motor domains at multiple steps in their ATPase cycles--including their nucleotide-free states--at ∼ 7 Å resolution using cryo-electron microscopy. In both motors, microtubule binding pro ...[more]