Ontology highlight
ABSTRACT:
SUBMITTER: Bao X
PROVIDER: S-EPMC4358366 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
eLife 20141104
Posttranslational modifications (PTMs) play a crucial role in a wide range of biological processes. Lysine crotonylation (Kcr) is a newly discovered histone PTM that is enriched at active gene promoters and potential enhancers in mammalian cell genomes. However, the cellular enzymes that regulate the addition and removal of Kcr are unknown, which has hindered further investigation of its cellular functions. Here we used a chemical proteomics approach to comprehensively profile 'eraser' enzymes t ...[more]