Ontology highlight
ABSTRACT:
SUBMITTER: Lim KJ
PROVIDER: S-EPMC4359323 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Lim Kah Jing KJ Brandt William D WD Heth Jason A JA Muraszko Karin M KM Fan Xing X Bar Eli E EE Eberhart Charles G CG
Oncotarget 20150101 3
During normal development, heterogeneous expression of Notch ligands can result in pathway suppression in the signal-sending cell, a process known as lateral inhibition. It is unclear if an analogous phenomenon occurs in malignant cells. We observed significant induction of Notch ligands in glioblastoma neurospheres and pancreatic carcinoma cells cultured in low oxygen, suggesting that this phenomenon could occur around hypoxic regions. To model lateral inhibition in these tumors, the ligand Jag ...[more]