Ontology highlight
ABSTRACT:
SUBMITTER: Taylor BJ
PROVIDER: S-EPMC4359381 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Taylor Benjamin J M BJ Wu Yee Ling YL Rada Cristina C
eLife 20140919
Cytidine deaminases are single stranded DNA mutators diversifying antibodies and restricting viral infection. Improper access to the genome leads to translocations and mutations in B cells and contributes to the mutation landscape in cancer, such as kataegis. It remains unclear how deaminases access double stranded genomes and whether off-target mutations favor certain loci, although transcription and opportunistic access during DNA repair are thought to play a role. In yeast, AID and the cataly ...[more]