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Phosphoinositides regulate ion channels.

ABSTRACT: Phosphoinositides serve as signature motifs for different cellular membranes and often are required for the function of membrane proteins. Here, we summarize clear evidence supporting the concept that many ion channels are regulated by membrane phosphoinositides. We describe tools used to test their dependence on phosphoinositides, especially phosphatidylinositol 4,5-bisphosphate, and consider mechanisms and biological meanings of phosphoinositide regulation of ion channels. This lipid regulation can underlie changes of channel activity and electrical excitability in response to receptors. Since different intracellular membranes have different lipid compositions, the activity of ion channels still in transit towards their final destination membrane may be suppressed until they reach an optimal lipid environment. This article is part of a Special Issue entitled Phosphoinositides.

SUBMITTER: Hille B

PROVIDER: S-EPMC4364932 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

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Phosphoinositides regulate ion channels.

Hille Bertil B Dickson Eamonn J EJ Kruse Martin M Vivas Oscar O Suh Byung-Chang BC

Biochimica et biophysica acta 20140918 6

Phosphoinositides serve as signature motifs for different cellular membranes and often are required for the function of membrane proteins. Here, we summarize clear evidence supporting the concept that many ion channels are regulated by membrane phosphoinositides. We describe tools used to test their dependence on phosphoinositides, especially phosphatidylinositol 4,5-bisphosphate, and consider mechanisms and biological meanings of phosphoinositide regulation of ion channels. This lipid regulatio ...[more]

PMID: 25241941

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