Ontology highlight
ABSTRACT:
SUBMITTER: Bishehsari F
PROVIDER: S-EPMC4368126 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Bishehsari Faraz F Gach Johannes S JS Akagi Naomi N Webber Molly K MK Bauer Jessica J Jung Barbara H BH
Oncoimmunology 20141114 8
Whereas the presence of autoantibodies in cancer patients has been acknowledged, their diagnostic or therapeutic significance has yet to be established. This is due, at least in part, to the lack of robust screening techniques to detect and characterize such antibodies for further assessment. In this study, we screened colorectal cancer (CRC) patient sera for antibodies specifically targeting the key cell cycle inhibitory factor p21 encoded by the cyclin-dependent kinase inhibitor 1A (CDKN1A). A ...[more]