Ontology highlight
ABSTRACT:
SUBMITTER: Vacchelli E
PROVIDER: S-EPMC4368132 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Vacchelli Erika E Pol Jonathan J Bloy Norma N Eggermont Alexander A Cremer Isabelle I Fridman Wolf Hervé WH Galon Jérôme J Marabelle Aurélien A Kohrt Holbrook H Zitvogel Laurence L Kroemer Guido G Galluzzi Lorenzo L
Oncoimmunology 20150101 1
An expanding panel of monoclonal antibodies (mAbs) that specifically target malignant cells or intercept trophic factors delivered by the tumor stroma is now available for cancer therapy. These mAbs can exert direct antiproliferative/cytotoxic effects as they inhibit pro-survival signal transduction cascades or activate lethal receptors at the plasma membrane of cancer cells, they can opsonize neoplastic cells to initiate a tumor-targeting immune response, or they can be harnessed to specificall ...[more]