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Trial watch: DNA-based vaccines for oncological indications.

ABSTRACT: DNA-based vaccination is a promising approach to cancer immunotherapy. DNA-based vaccines specific for tumor-associated antigens (TAAs) are indeed relatively simple to produce, cost-efficient and well tolerated. However, the clinical efficacy of DNA-based vaccines for cancer therapy is considerably limited by central and peripheral tolerance. During the past decade, considerable efforts have been devoted to the development and characterization of novel DNA-based vaccines that would circumvent this obstacle. In this setting, particular attention has been dedicated to the route of administration, expression of modified TAAs, co-expression of immunostimulatory molecules, and co-delivery of immune checkpoint blockers. Here, we review preclinical and clinical progress on DNA-based vaccines for cancer therapy.

SUBMITTER: Pierini S

PROVIDER: S-EPMC5706602 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Trial watch: DNA-based vaccines for oncological indications.

Pierini Stefano S Perales-Linares Renzo R Uribe-Herranz Mireia M Pol Jonathan G JG Zitvogel Laurence L Kroemer Guido G Facciabene Andrea A Galluzzi Lorenzo L

Oncoimmunology 20171120 12

DNA-based vaccination is a promising approach to cancer immunotherapy. DNA-based vaccines specific for tumor-associated antigens (TAAs) are indeed relatively simple to produce, cost-efficient and well tolerated. However, the clinical efficacy of DNA-based vaccines for cancer therapy is considerably limited by central and peripheral tolerance. During the past decade, considerable efforts have been devoted to the development and characterization of novel DNA-based vaccines that would circumvent th ...[more]

PMID: 29209575

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