Ontology highlight
ABSTRACT:
SUBMITTER: Klein W
PROVIDER: S-EPMC4373898 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Klein Wolfgang W Westendorf Carolin C Schmidt Antje A Conill-Cortés Mercè M Rutz Claudia C Blohs Marcus M Beyermann Michael M Protze Jonas J Krause Gerd G Krause Eberhard E Schülein Ralf R
PloS one 20150325 3
The cyclodepsipeptide cotransin was described to inhibit the biosynthesis of a small subset of proteins by a signal sequence-discriminatory mechanism at the Sec61 protein-conducting channel. However, it was not clear how selective cotransin is, i.e. how many proteins are sensitive. Moreover, a consensus motif in signal sequences mediating cotransin sensitivity has yet not been described. To address these questions, we performed a proteomic study using cotransin-treated human hepatocellular carci ...[more]