Antibacterial properties and atomic resolution X-ray complex crystal structure of a ruthenocene conjugated ?-lactam antibiotic.
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ABSTRACT:
SUBMITTER: Lewandowski EM
PROVIDER: S-EPMC4374039 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Publications
Antibacterial properties and atomic resolution X-ray complex crystal structure of a ruthenocene conjugated β-lactam antibiotic.
Lewandowski Eric M EM Skiba Joanna J Torelli Nicholas J NJ Rajnisz Aleksandra A Solecka Jolanta J Kowalski Konrad K Chen Yu Y
Chemical communications (Cambridge, England) 20150401 28
We have determined a 1.18 Å resolution X-ray crystal structure of a novel ruthenocenyle-6-aminopenicillinic acid in complex with CTX-M β-lactamase, showing unprecedented details of interactions between ruthenocene and protein. As the first product complex with an intact catalytic serine, the structure also offers insights into β-lactamase catalysis and inhibitor design. ...[more]
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