Ontology highlight
ABSTRACT:
SUBMITTER: Tzarum N
PROVIDER: S-EPMC4374348 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Tzarum Netanel N de Vries Robert P RP Zhu Xueyong X Yu Wenli W McBride Ryan R Paulson James C JC Wilson Ian A IA
Cell host & microbe 20150301 3
Avian influenza viruses that cause infection and are transmissible in humans involve changes in the receptor binding site (RBS) of the viral hemagglutinin (HA) that alter receptor preference from α2-3-linked (avian-like) to α2-6-linked (human-like) sialosides. A human case of avian-origin H6N1 influenza virus was recently reported, but the molecular mechanisms contributing to it crossing the species barrier are unknown. We find that, although the H6 HA RBS contains D190V and G228S substitutions ...[more]