Ontology highlight
ABSTRACT:
SUBMITTER: Zeraati M
PROVIDER: S-EPMC5429658 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Zeraati Mahdi M Moye Aaron L AL Wong Jason W H JWH Perera Dilmi D Cowley Mark J MJ Christ Daniel U DU Bryan Tracy M TM Dinger Marcel E ME
Scientific reports 20170406 1
Cancer is a multifactorial disease driven by a combination of genetic and environmental factors. Many cancer driver mutations have been characterised in protein-coding regions of the genome. However, mutations in noncoding regions associated with cancer have been less investigated. G-quadruplex (G4) nucleic acids are four-stranded secondary structures formed in guanine-rich sequences and prevalent in the regulatory regions. In this study, we used published whole cancer genome sequence data to fi ...[more]