Ontology highlight
ABSTRACT:
SUBMITTER: Gang Q
PROVIDER: S-EPMC4378665 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Gang Qiang Q Bettencourt Conceicao C Machado Pedro M PM Fox Zoe Z Brady Stefen S Healy Estelle E Parton Matt M Holton Janice L JL Hilton-Jones David D Shieh Perry B PB Zanoteli Edmar E De Paepe Boel B De Bleecker Jan J Shaibani Aziz A Ripolone Michela M Violano Raffaella R Moggio Maurizio M Barohn Richard J RJ Dimachkie Mazen M MM Mora Marina M Mantegazza Renato R Zanotti Simona S Hanna Michael G MG Houlden Henry H
Neurobiology of aging 20150114 4
A previous study showed that, in carriers of the apolipoprotein E (APOE) genotype ε3/ε3 or ε3/ε4, the presence of a very long (VL) polyT repeat allele in "translocase of outer mitochondrial membrane 40" (TOMM40) was less frequent in patients with sporadic inclusion body myositis (sIBM) compared with controls and associated with a later age of sIBM symptom onset, suggesting a protective effect of this haplotype. To further investigate the influence of these genetic factors in sIBM, we analyzed a ...[more]