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Melanoma-derived mediators can foster the premetastatic niche: crossroad to lymphatic metastasis.

ABSTRACT: The natural history of advanced malignant melanoma demonstrates that, in most cases, widespread tumor dissemination is preceded by regional metastases involving tumor-draining lymph nodes [sentinel lymph nodes (SLNs)]. Under physiological conditions, LNs play a central role in immunosurveillance to non-self-antigens to which they are exposed via afferent lymph. The dysfunctional immunity in SLNs is mediated by tumor secretory factors that allow the survival of metastatic melanoma cells within the LN by creating a premetastatic niche (PMN). Recent studies outline the altered microenvironment of LNs shaped by melanoma mediators. Here, we discuss tumor secretory factors involved in subverting tumor immunity and remodeling LNs and highlight emerging therapeutic strategies to reinvigorate antitumoral immunity in SLNs.

SUBMITTER: Suman S

PROVIDER: S-EPMC10528107 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature

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Melanoma-derived mediators can foster the premetastatic niche: crossroad to lymphatic metastasis.

Suman Shankar S Markovic Svetomir N SN

Trends in immunology 20230810 9

The natural history of advanced malignant melanoma demonstrates that, in most cases, widespread tumor dissemination is preceded by regional metastases involving tumor-draining lymph nodes [sentinel lymph nodes (SLNs)]. Under physiological conditions, LNs play a central role in immunosurveillance to non-self-antigens to which they are exposed via afferent lymph. The dysfunctional immunity in SLNs is mediated by tumor secretory factors that allow the survival of metastatic melanoma cells within th ...[more]

PMID: 37573226

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