Ontology highlight
ABSTRACT:
SUBMITTER: Nicolae CM
PROVIDER: S-EPMC4381061 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Nicolae Claudia M CM Aho Erin R ER Choe Katherine N KN Constantin Daniel D Hu He-Juan HJ Lee Deokjae D Myung Kyungjae K Moldovan George-Lucian GL
Nucleic acids research 20150309 6
Genomic instability, a major hallmark of cancer cells, is caused by incorrect or ineffective DNA repair. Many DNA repair mechanisms cooperate in cells to fight DNA damage, and are generally regulated by post-translational modification of key factors. Poly-ADP-ribosylation, catalyzed by PARP1, is a post-translational modification playing a prominent role in DNA repair, but much less is known about mono-ADP-ribosylation. Here we report that mono-ADP-ribosylation plays an important role in homologo ...[more]