Long-chain ω-3 fatty acid intake and endometrial cancer risk in the Women's Health Initiative.

ABSTRACT:

Background

Inflammation may be important in endometrial cancer development. Long-chain ω-3 (n-3) polyunsaturated fatty acids (LCω-3PUFAs) may reduce inflammation and, therefore, reduce cancer risk. Because body mass is associated with both inflammation and endometrial cancer risk, it may modify the association of fat intake on risk.

Objective

We examined whether intakes of LCω-3PUFAs were associated with endometrial cancer risk overall and stratified by body size and histologic subtype.

Design

Women were n = 87,360 participants of the Women's Health Initiative Observational Study and Clinical Trials who were aged 50-79 y, had an intact uterus, and completed a baseline food-frequency questionnaire. After 13 y of follow-up, n = 1253 incident invasive endometrial cancers

SUBMITTER: Brasky TM 

PROVIDER: S-EPMC4381777 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature