Ontology highlight
ABSTRACT:
SUBMITTER: Wang KP
PROVIDER: S-EPMC4385690 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Wang Kun-Ping KP Zhang Chao C Zhang Shou-Guo SG Liu En-Dong ED Dong Lan L Kong Xiang-Zhen XZ Cao Peng P Hu Chun-Ping CP Zhao Ke K Zhan Yi-Qun YQ Dong Xiao-Ming XM Ge Chang-Hui CH Yu Miao M Chen Hui H Wang Lin L Yang Xiao-Ming XM Li Chang-Yan CY
Oxidative medicine and cellular longevity 20150322
Nrf2 is the key transcription factor regulating the antioxidant response which is crucial for cytoprotection against extracellular stresses. Numerous in vivo studies indicate that Nrf2 plays a protective role in anti-inflammatory response. 3-(3-Pyridylmethylidene)-2-indolinone (PMID) is a synthesized derivative of 2-indolinone compounds. Our previous study suggested that PMID induces the activation of Nrf2/ARE pathway, then protecting against oxidative stress-mediated cell death. However, little ...[more]