Ontology highlight
ABSTRACT:
SUBMITTER: Beich-Frandsen M
PROVIDER: S-EPMC4388265 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Beich-Frandsen Mads M Aragón Eric E Llimargas Marta M Benach Jordi J Riera Antoni A Pous Joan J Macias Maria J MJ
Acta crystallographica. Section D, Biological crystallography 20150326 Pt 4
Gene-expression changes observed in Drosophila embryos after inducing the transcription factor Tramtrack led to the identification of the protein Expansion. Expansion contains an N-terminal domain similar in sequence to the MH2 domain characteristic of Smad proteins, which are the central mediators of the effects of the TGF-β signalling pathway. Apart from Smads and Expansion, no other type of protein belonging to the known kingdoms of life contains MH2 domains. To compare the Expansion and Smad ...[more]