Ontology highlight
ABSTRACT:
SUBMITTER: Maruani A
PROVIDER: S-EPMC4389247 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Maruani Antoine A Smith Mark E B ME Miranda Enrique E Chester Kerry A KA Chudasama Vijay V Caddick Stephen S
Nature communications 20150331
Although recent methods for the engineering of antibody-drug conjugates (ADCs) have gone some way to addressing the challenging issues of ADC construction, significant hurdles still remain. There is clear demand for the construction of novel ADC platforms that offer greater stability, homogeneity and flexibility. Here we describe a significant step towards a platform for next-generation antibody-based therapeutics by providing constructs that combine site-specific modification, exceptional versa ...[more]