Ontology highlight
ABSTRACT:
SUBMITTER: Sun L
PROVIDER: S-EPMC4871752 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Sun Lingyi L Ding Jiule J Xing Wei W Gai Yongkang Y Sheng Jing J Zeng Dexing D
Bioconjugate chemistry 20160427 5
Preparation of small molecule based dual-modality probes remains a challenging task due to the complicated synthetic procedure. In this study, a novel concise and generic strategy for preparing dual-modality optical/PET imaging probes via photo-click chemistry was developed, in which the diazole photo-click linker functioned not only as a bridge between the targeting-ligand and the PET imaging moiety, but also as the fluorophore for optical imaging. A dual-modality AE105 peptidic probe was succe ...[more]