Origin and spread of de novo genes in Drosophila melanogaster populations.
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ABSTRACT:
SUBMITTER: Zhao L
PROVIDER: S-EPMC4391638 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Publications
Origin and spread of de novo genes in Drosophila melanogaster populations.
Zhao Li L Saelao Perot P Jones Corbin D CD Begun David J DJ
Science (New York, N.Y.) 20140123 6172
Comparative genomic analyses have revealed that genes may arise from ancestrally nongenic sequence. However, the origin and spread of these de novo genes within populations remain obscure. We identified 142 segregating and 106 fixed testis-expressed de novo genes in a population sample of Drosophila melanogaster. These genes appear to derive primarily from ancestral intergenic, unexpressed open reading frames, with natural selection playing a significant role in their spread. These results revea ...[more]
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