Ontology highlight
ABSTRACT:
SUBMITTER: Feng J
PROVIDER: S-EPMC6318269 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Oncogene 20180806 1
Ectopic epigenetic mechanisms play important roles in facilitating tumorigenesis. Here, we first demonstrated that ANKDD1A is a functional tumor suppressor gene, especially in the hypoxia microenvironment. ANKDD1A directly interacts with FIH1 and inhibits the transcriptional activity of HIF1α by upregulating FIH1. In addition, ANKDD1A decreases the half-life of HIF1α by upregulating FIH1, decreases glucose uptake and lactate production, inhibits glioblastoma multiforme (GBM) autophagy, and induc ...[more]