A signal-to-cutoff ratio in the Abbott architect HIV Ag/Ab Combo assay that predicts subsequent confirmation of HIV-1 infection in a low-prevalence setting.
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ABSTRACT:
SUBMITTER: Jensen TO
PROVIDER: S-EPMC4400779 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
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A signal-to-cutoff ratio in the Abbott architect HIV Ag/Ab Combo assay that predicts subsequent confirmation of HIV-1 infection in a low-prevalence setting.
Jensen Tomas Ostergaard TO Robertson Peter P Whybin Ross R Chambers Ian I Lahra Monica M Rawlinson William W Post Jeffrey John JJ
Journal of clinical microbiology 20150211 5
A rapid diagnosis is considered important in HIV care. In 138,911 testing episodes with the Abbott Architect HIV Ag/Ab Combo assay (3,705 reactive samples), a signal-to-cutoff ratio of >151.17 had a positive predictive value of 100% and a sensitivity of 67.4% for the detection of subsequently confirmed HIV infection. We suggest that results higher than this signal-to-cutoff ratio threshold may be reported to clinicians before the completion of confirmatory testing. ...[more]
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