Dataset Information
Mir-196a-2 C>T polymorphism as a susceptibility factor for colorectal cancer.
Ontology highlight
ABSTRACT: Objective
This study aimed to gain a better insight into the impact of the mir-196a-2 C>T polymorphism on the susceptibility to colorectal cancer (CRC).Methods
In a meta-analysis of 6 publications with a total of 1,754 cancer cases and 2,430 controls, we summarized the data on the associations between the studied mir-196a-2 C>T polymorphism and CRC risk and conducted subgroup analyses by ethnicity and control sources.Results
We found no overall association between the mir-196a-2 C>T polymorphism and CRC risk. But a significant association was found in the stratified analysis according to ethnicity among Asians (ORCC vs. TT = 1.22, 95% CI = 1.02-1.45, P heterogeneity = 0.718; ORCC vs. TC + TT = 1.22, 95% CI = 1.04-1.44, P heterogeneity = 0.590; ORallele C vs. allele T = 1.10, 95% CI = 1.01-1.20, P heterogeneity = 0.726) rather than Caucasians.Conclusions
Our results suggested that there was no overall risk of CRC in relation to the mir-196a-2 C>T polymorphism. However, this polymorphism was associated with an increased risk in Asian populations.
SUBMITTER: Shi L
PROVIDER: S-EPMC4402854 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Mir-196a-2 C>T polymorphism as a susceptibility factor for colorectal cancer.
International journal of clinical and experimental medicine 20150215 2
<h4>Objective</h4>This study aimed to gain a better insight into the impact of the mir-196a-2 C>T polymorphism on the susceptibility to colorectal cancer (CRC).<h4>Methods</h4>In a meta-analysis of 6 publications with a total of 1,754 cancer cases and 2,430 controls, we summarized the data on the associations between the studied mir-196a-2 C>T polymorphism and CRC risk and conducted subgroup analyses by ethnicity and control sources.<h4>Results</h4>We found no overall association between the mir ...[more]