A draft map of the human proteome.
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ABSTRACT:
SUBMITTER: Kim MS
PROVIDER: S-EPMC4403737 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Publications
A draft map of the human proteome.
Kim Min-Sik MS Pinto Sneha M SM Getnet Derese D Nirujogi Raja Sekhar RS Manda Srikanth S SS Chaerkady Raghothama R Madugundu Anil K AK Kelkar Dhanashree S DS Isserlin Ruth R Jain Shobhit S Thomas Joji K JK Muthusamy Babylakshmi B Leal-Rojas Pamela P Kumar Praveen P Sahasrabuddhe Nandini A NA Balakrishnan Lavanya L Advani Jayshree J George Bijesh B Renuse Santosh S Selvan Lakshmi Dhevi N LD Patil Arun H AH Nanjappa Vishalakshi V Radhakrishnan Aneesha A Prasad Samarjeet S Subbannayya Tejaswini T Raju Rajesh R Kumar Manish M Sreenivasamurthy Sreelakshmi K SK Marimuthu Arivusudar A Sathe Gajanan J GJ Chavan Sandip S Datta Keshava K KK Subbannayya Yashwanth Y Sahu Apeksha A Yelamanchi Soujanya D SD Jayaram Savita S Rajagopalan Pavithra P Sharma Jyoti J Murthy Krishna R KR Syed Nazia N Goel Renu R Khan Aafaque A AA Ahmad Sartaj S Dey Gourav G Mudgal Keshav K Chatterjee Aditi A Huang Tai-Chung TC Zhong Jun J Wu Xinyan X Shaw Patrick G PG Freed Donald D Zahari Muhammad S MS Mukherjee Kanchan K KK Shankar Subramanian S Mahadevan Anita A Lam Henry H Mitchell Christopher J CJ Shankar Susarla Krishna SK Satishchandra Parthasarathy P Schroeder John T JT Sirdeshmukh Ravi R Maitra Anirban A Leach Steven D SD Drake Charles G CG Halushka Marc K MK Prasad T S Keshava TS Hruban Ralph H RH Kerr Candace L CL Bader Gary D GD Iacobuzio-Donahue Christine A CA Gowda Harsha H Pandey Akhilesh A
Nature 20140501 7502
The availability of human genome sequence has transformed biomedical research over the past decade. However, an equivalent map for the human proteome with direct measurements of proteins and peptides does not exist yet. Here we present a draft map of the human proteome using high-resolution Fourier-transform mass spectrometry. In-depth proteomic profiling of 30 histologically normal human samples, including 17 adult tissues, 7 fetal tissues and 6 purified primary haematopoietic cells, resulted i ...[more]
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