A draft map of the human proteome

ABSTRACT: The availability of human genome sequence has transformed biomedical research over the past decade. However, an equivalent map for the human proteome with direct measurements of proteins and peptides does not exist yet. Here, we report a draft map of the human proteome based on high resolution Fourier transform mass spectrometry-based proteomics technology. In-depth proteomic profiling of 30 histologically normal human samples including 17 adult tissues, 7 fetal tissues and 6 purified primary hematopoietic cells resulted in identification of proteins encoded by greater than 17,000 genes accounting for ~84% of the total annotated protein-coding genes in humans. This large human proteome catalog (available as an interactive web-based resource at http://www.humanproteomemap.org) will complement available human genome and transcriptome data to accelerate biomedical research in health and disease. The authors request that those considering use of this dataset for commercial purposes contact [e-mail].

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OTHER RELATED OMICS DATASETS IN: E-PROT-1 MSV000079514 E-PROT-3 PAe005095 PAe004968 PAe004965 PAe004962 PAe005041 PAe005027 PAe004741 PAe004746 PAe004935 PAe004880 PAe004896 PAe004876 PAe004953 PAe004999 PAe004826 PAe005001 PAe005004

INSTRUMENT(S): LTQ Orbitrap Velos, LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Heart, Testis, Brain, Prostate Gland, Lung, Liver, Retina, Natural Killer Cell, Kidney, Blood Platelet, Ovary, Helper T-lymphocyte, Colon, Pancreas, Monocyte, Gall Bladder, Cytotoxic T-lymphocyte, Gut, Esophagus, Placenta, Frontal Lobe, Spinal Cord, Rectum, B-lymphocyte, Urinary Bladder, Adrenal Gland

SUBMITTER: Akhilesh Pandey  

LAB HEAD: Akhilesh Pandey

PROVIDER: PXD000561 | Pride | 2014-04-24

REPOSITORIES: Pride