Dataset Information

A draft map of the human proteome

ABSTRACT: The availability of human genome sequence has transformed biomedical research over the past decade. However, an equivalent map for the human proteome with direct measurements of proteins and peptides does not exist yet. Here, we report a draft map of the human proteome based on high resolution Fourier transform mass spectrometry-based proteomics technology. In-depth proteomic profiling of 30 histologically normal human samples including 17 adult tissues, 7 fetal tissues and 6 purified primary hematopoietic cells resulted in identification of proteins encoded by greater than 17,000 genes accounting for ~84% of the total annotated protein-coding genes in humans. This large human proteome catalog (available as an interactive web-based resource at http://www.humanproteomemap.org) will complement available human genome and transcriptome data to accelerate biomedical research in health and disease. The authors request that those considering use of this dataset for commercial purposes contact pandey@jhmi.edu.

INSTRUMENT(S): LTQ Orbitrap Velos, LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Dr Akhilesh Pandey

PROVIDER: MSV000079514 | MassIVE | Tue Feb 16 10:39:00 GMT 2016

SECONDARY ACCESSION(S): PXD000561

REPOSITORIES: MassIVE

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Functional annotation of proteome encoded by human chromosome 22.

Pinto Sneha M SM Manda Srikanth S SS Kim Min-Sik MS Taylor KyOnese K Selvan Lakshmi Dhevi Nagarajha LD Balakrishnan Lavanya L Subbannayya Tejaswini T Yan Fangfei F Prasad T S Keshava TS Gowda Harsha H Lee Charles C Hancock William S WS Pandey Akhilesh A

Journal of proteome research 20140429 6

As part of the chromosome-centric human proteome project (C-HPP) initiative, we report our progress on the annotation of chromosome 22. Chromosome 22, spanning 51 million base pairs, was the first chromosome to be sequenced. Gene dosage alterations on this chromosome have been shown to be associated with a number of congenital anomalies. In addition, several rare but aggressive tumors have been associated with this chromosome. A number of important gene families including immunoglobulin lambda l ...[more]

PMID: 24669763

Publication: 1/2

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