Ontology highlight
ABSTRACT:
SUBMITTER: Beaulieu AM
PROVIDER: S-EPMC4404304 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Beaulieu Aimee M AM Zawislak Carolyn L CL Nakayama Toshinori T Sun Joseph C JC
Nature immunology 20140420 6
Natural killer (NK) cells are innate lymphocytes that exhibit many features of adaptive immunity, including clonal proliferation and long-lived memory. Here we demonstrate that the BTB-ZF transcription factor Zbtb32 (also known as ROG, FAZF, TZFP and PLZP) was essential for the proliferative burst and protective capacity of virus-specific NK cells. Signals from proinflammatory cytokines were both necessary and sufficient to induce high expression of Zbtb32 in NK cells. Zbtb32 facilitated NK cell ...[more]