Ontology highlight
ABSTRACT:
SUBMITTER: Wilson C
PROVIDER: S-EPMC4405104 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Wilson C C Agafonov R V RV Hoemberger M M Kutter S S Zorba A A Halpin J J Buosi V V Otten R R Waterman D D Theobald D L DL Kern D D
Science (New York, N.Y.) 20150201 6224
Macromolecular function is rooted in energy landscapes, where sequence determines not a single structure but an ensemble of conformations. Hence, evolution modifies a protein's function by altering its energy landscape. Here, we recreate the evolutionary pathway between two modern human oncogenes, Src and Abl, by reconstructing their common ancestors. Our evolutionary reconstruction combined with x-ray structures of the common ancestor and pre-steady-state kinetics reveals a detailed atomistic m ...[more]