Ontology highlight
ABSTRACT:
SUBMITTER: Kaya A
PROVIDER: S-EPMC4406665 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Kaya Alaattin A Lobanov Alexei V AV Gladyshev Vadim N VN
Aging cell 20150222 3
The concept that mutations cause aging phenotypes could not be directly tested previously due to inability to identify age-related mutations in somatic cells and determine their impact on organismal aging. Here, we subjected Saccharomyces cerevisiae to multiple rounds of replicative aging and assessed de novo mutations in daughters of mothers of different age. Mutations did increase with age, but their low numbers, < 1 per lifespan, excluded their causal role in aging. Structural genome changes ...[more]