Ontology highlight
ABSTRACT:
SUBMITTER: Cohen A
PROVIDER: S-EPMC4749178 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Cohen Aviv A Weindling Esther E Rabinovich Efrat E Nachman Iftach I Fuchs Shai S Chuartzman Silvia S Gal Lihi L Schuldiner Maya M Bar-Nun Shoshana S
PloS one 20160210 2
Transferring Saccharomyces cerevisiae cells to water is known to extend their lifespan. However, it is unclear whether this lifespan extension is due to slowing the aging process or merely keeping old yeast alive. Here we show that in water-transferred yeast, the toxicity of polyQ proteins is decreased and the aging biomarker 47Q aggregates at a reduced rate and to a lesser extent. These beneficial effects of water-transfer could not be reproduced by diluting the growth medium and depended on de ...[more]