Ontology highlight
ABSTRACT:
SUBMITTER: Melgarejo da Rosa M
PROVIDER: S-EPMC4978723 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Melgarejo da Rosa Michelle M Yuanxiang PingAn P Brambilla Riccardo R Kreutz Michael R MR Karpova Anna A
Frontiers in molecular neuroscience 20160810
A central pathway in synaptic plasticity couples N-Methyl-D-Aspartate-receptor (NMDAR)-signaling to the activation of extracellular signal-regulated kinases (ERKs) cascade. ERK-dependency has been demonstrated for several forms of synaptic plasticity as well as learning and memory and includes local synaptic processes but also long-distance signaling to the nucleus. It is, however, controversial how NMDAR signals are connected to ERK activation in dendritic spines and nuclear import of ERK. The ...[more]