Ontology highlight
ABSTRACT:
SUBMITTER: Cheng S
PROVIDER: S-EPMC4411097 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Cheng Shujie S Swanson Kristen K Eliaz Isaac I McClintick Jeanette N JN Sandusky George E GE Sliva Daniel D
PloS one 20150427 4
Pachymic acid (PA) is a purified triterpene extracted from medicinal fungus Poria cocos. In this paper, we investigated the anticancer effect of PA on human chemotherapy resistant pancreatic cancer. PA triggered apoptosis in gemcitabine-resistant pancreatic cancer cells PANC-1 and MIA PaCa-2. Comparative gene expression array analysis demonstrated that endoplasmic reticulum (ER) stress was induced by PA through activation of heat shock response and unfolded protein response related genes. Induce ...[more]