Ontology highlight
ABSTRACT:
SUBMITTER: Thakur C
PROVIDER: S-EPMC4414149 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Thakur Chitra C Wolfarth Michael M Sun Jiaying J Zhang Yadong Y Lu Yongju Y Battelli Lori L Porter Dale W DW Chen Fei F
Oncotarget 20150201 6
Mineral dust-induced gene (mdig, also named Mina53) was first identified from alveolar macrophages of the coal miners with chronic lung inflammation or fibrosis, but how this gene is involved in lung diseases is poorly understood. Here we show that heterozygotic knockout of mdig (mdig+/-) ameliorates silica-induced lung fibrosis by altering the balance between Th17 cells and Treg cells. Relative to the wild type (WT) mice, infiltration of the macrophages and Th17 cells was reduced in lungs from ...[more]