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Anti-HLA alloantibodies in surgical patients refractory to platelet transfusion.

ABSTRACT: Alloimmune platelet refractoriness (alloPR) among actively bleeding surgical patients with thrombocytopenia represents a life-threatening problem. Here we present three cases in which surgical bleeding was complicated by life-threatening thrombocytopenia and alloPR. We demonstrate that the human leukocyte antigens (HLA) antibodies associated with alloPR are broadly reactive and in high concentration, are not removed by hemodilution, and are not absorbed by transfusion of multiple doses of platelet concentrates. HLA alloPR may be under-recognized among surgical patients. Research is needed to develop pre-operative screening methods that will identify patients in need of specialized platelet support using HLA compatible donor products.

SUBMITTER: Pena JR

PROVIDER: S-EPMC4416418 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature

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Anti-HLA alloantibodies in surgical patients refractory to platelet transfusion.

Peña Jeremy Ryan A JR Saidman Susan L SL Girouard Timothy C TC Meister Erin E Dzik Walter H WH Makar Robert S RS

American journal of hematology 20140619 9

Alloimmune platelet refractoriness (alloPR) among actively bleeding surgical patients with thrombocytopenia represents a life-threatening problem. Here we present three cases in which surgical bleeding was complicated by life-threatening thrombocytopenia and alloPR. We demonstrate that the human leukocyte antigens (HLA) antibodies associated with alloPR are broadly reactive and in high concentration, are not removed by hemodilution, and are not absorbed by transfusion of multiple doses of platel ...[more]

PMID: 24816643

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